13C urea breath test (UBT) in the diagnosis of Helicobacter pylori: why does it work better with acid test meals?

STOMACH 13 C urea breath test ( UBT ) in the diagnosis of Helicobacter pylori : why does it work better with acid test meals ?

Background: Acid test meals may improve the accuracy of the C urea breath test (UBT). This has been attributed to changes in gastric emptying rather than to the effects of gastric pH on Helicobacter pylori urease. Aims: To determine whether enhancement of CO2 excretion in the UBT in H pylori infected volunteers by acidification of a test meal is due to a delay in gastric emptying. Methods: Urea...

Limitations of C-urea Breath Test (ubt) and Stool Antigen Test (sat) in Diagnosis of Helicobacter Pylori (hp) Infections

Helicobacter pylori (HP)(1) management (including diagnosis and therapy) has been exhaustively reviewed in several reports. These reports are unanimous in that several clinical conditions seriously hamper the diagnostic value of two HP tests: 13 C-Urea Breath Test (UBT) and Stool Antigen test (SAT), because of the false-negative results frequently (up to 40%) obtained in these conditions. Basic...

The 13C urea breath test in the diagnosis of Helicobacter pylori infection.

The urea breath test (UBT) is one of the most important non-invasive methods for detecting Helicobacter pylori infection. The test exploits the hydrolysis of orally administered urea by the enzyme urease, which H pylori produces in large quantities. Urea is hydrolysed to ammonia and carbon dioxide, which diffuses into the blood and is excreted by the lungs. Isotopically labelled CO2 can be dete...

The urea breath test for Helicobacter pylori.

[Validation of a simplified 13C-urea breath test method for the diagnosis of Helicobacter pylori infection].

OBJECTIVE To validate a simplified 13C-urea breath test (13C-UBT) method for the diagnosis of H. pylori infection. MATERIAL AND METHODS Patients referred for gastrointestinal endoscopy and biopsy were included, and a 13C-UBT was performed after a 6-hour fast. Breath samples were collected in 10 ml glass tubes before and 30 min after the simultaneous administration of 50 mg of 13C-urea and 2 g...